At the Zeisel molecular neurobiology lab we aim to understand patterns of neuronal connectivity. Neurons communicate via synapses, wired to complex networks. Very little is understood about the connectivity rules both for distant and locally projecting neurons. The relationship between cellular identity (as reflected by gene expression) and network properties are even less described. We apply molecular tools and measurements to shed more light on these topics.
Our second aim is to study molecular changes at the level of gene expression that occur as part of learning and memory. We combine cutting-edge molecular biology tools with behavioral experiments in mice and other organisms, to identify and describe regions involved in learning.
In an exciting new venture outside the nervous system, we dissect the molecular building blocks of the placenta – and how this organ differs between hypertensive pregnancy disorder preeclampsia, and healthy pregnancies.